The great advantage of the Hotel Margaret Rome is its close vicinity to Termini Station - the main transport hub of Rome that accommodates a taxi rank, a bus station, a train station with direct links to the airports and the rest of Italy and a coach rank. The hotel is located at 6 Via Antonio Salandra and the map below shows the brevity of the walk from Termini to the doors of the hotel.
There are direct train transfers from the port to Termini station.
From Fiumicino airport (FCO) there is a direct train shuttle to take passengers directly from the airport into Termini station. There is also a much cheaper private coach service that can also transport passengers to Termini.
From Ciampino airport (CIA) there is a cheap private coach service to transport passengers to Termini.